Regulation of apoptosis and cell cycle Biology Diagrams The role of c‐Myc in cell cycle and apoptosis. Besides its role in cell cycle, c‐Myc also plays a key role in regulating apoptosis. This role was confirmed in different cell types under a wide variety of physiological conditions and both under‐ and overexpression of c‐Myc can lead to cell death (reviewed in Conzen et al. 2000 and Thompson 1998). An argument in favor of a link between the cell cycle and apoptosis arises from the accumulated evidence that manipulation of the cell cycle may either prevent or induce an apoptotic response. This linkage has been recognized for tumor suppressor genes such as p53 and RB , the dominant oncogene, c- Myc , and several cyclin-dependent kinases
Apoptosis vs Necrosis. Animated Video explaining in detail the differences between Necrosis and Apoptosis. A project of Free Medical Education . Explore the cell cycle with the Amoeba Sisters and an important example of when it is not controlled: cancer. Stem cells. Stem Cells.pdf. Stem cells. PDF of presentation shown in class. Defines Several lines of reasoning indicate that apoptosis and cell proliferation coincide to some degree: many oncogenes that promote cell cycle progression also induce apoptosis; damage to the cell cycle or to DNA integrity is a potent trigger of apoptosis; and the key tumour suppressor proteins, p105 rb and p53, exert direct effects both on cell Additionally, cell cycle checkpoints appear to link the cell cycle to apoptosis. Deregulation of the cell cycle components has been shown to induce mitotic catastrophe and also may be involved in triggering apoptosis. Some apoptotic cells express abnormal levels of cell cycle proteins and often contain active Cdc2, the primary kinase active
Cell Cycle and Apoptosis Biology Diagrams
Cell death, like apoptosis and autophagy, are natural processes. Cells die or recycle to make way for newer, more efficient ones. Your body expects these programmed cell deaths to happen. Necrosis (unexpected cell death from lack of blood flow) causes tissue death. When cell death doesn't happen as it should, cancers and other problems occur. Cell cycle and apoptosis 167 Besides its role in cell cycle, c-Myc also plays a key role in regulating apoptosis. This role was confirmed in different cell types under a wide variety of physiological conditions and both under- and overexpression of c-Myc can lead to cell death (reviewed in Conzen et al. 2000 and Thompson 1998). Several lines of reasoning indicate that apoptosis and cell proliferation coincide to some degree: many oncogenes that promote cell cycle progression also induce apoptosis; damage to the cell cycle or to DNA integrity is a potent trigger of apoptosis; and the key tumour suppressor proteins, p105rb and p53, exert direct effects both on cell
The linkage of cell cycle and apoptosis has been recognized for c-Myc, p53, pRb, Ras, PKA, PKC, Bcl-2, NF-kappa B, CDK, cyclins and CKI. This review summarizes the different functions of the proteins presently known to control both apoptosis and cell cycle progression. These proteins can influence apoptosis or proliferation but different
